be up against it idiom informal
陷入（或面临）困境
to be having or likely to have serious problems or difficulties
With seven members of the team missing, Hull are going to be up against it. 缺了7名队员，赫尔城队形势严峻。
Many families are up against it, unable to afford even basic items. 很多家庭陷入困境，连基本生活用品都买不起。