anguish
noun [ U ] uk/ˈæŋ.ɡwɪʃ/ us/ˈæŋ.ɡwɪʃ/
（肉体或精神上的）极度痛苦，剧痛，悲痛
extreme unhappiness caused by physical or mental suffering
His anguish at the outcome of the court case was very clear. 得知案子的庭审结果，他痛苦欲绝，这是显而易见的。
In her anguish she forgot to leave a message. 万分悲痛之中，她忘了留个口信。