demented
adjective uk/dɪˈmen.tɪd/ us/dɪˈmen.t̬ɪd/
忧虑失常的;疯狂的;昏了头的，懵了的
unable to think or act clearly because you are extremely worried, angry, or excited by something
She was nearly demented with worry when her son didn't come home. 当儿子没有回家时，她几乎要急疯了。
old-fashioned or informal精神错乱的，精神不正常的
crazy
The man is demented - he's going to wreck the whole operation. 那个人精神不正常——他会毁了整个行动。