irreversible
adjective uk/ˌɪr.ɪˈvɜː.sə.bəl/ us/ˌɪr.əˈvɝː.sə.bəl/
C2 不可改变的，不可逆转的
not possible to change; impossible to return to a previous condition
Smoking has caused irreversible damage to his lungs. 吸烟已经对他的肺部造成了永久的损害。
Opposite: reversible