vicissitudes
noun [ plural ] formal uk/vɪˈsɪs.ɪ.tʃuːdz/ us/vɪˈsɪs.ə.tuːdz/
变迁；人生沉浮；波折
changes that happen at different times during the life or development of someone or something, especially those that result in conditions being worse
Losing your job is just one of the vicissitudes of life. 失业只是曲折人生中的一个插曲。